Polynucleotides in Aesthetics: The Next Generation of Skin Rejuvenation
- nursemeicha
- Apr 16
- 4 min read
Table of Contents
Introduction
What Are Polynucleotides?
How They Work
Benefits
Who They're For
What to Expect
Comparing to Fillers
Safety
Results
Pricing
Why Choose Us
FAQs
Book Your Consultation
1. Introduction
Let me say this upfront: not everyone wants fillers. Some of us just want our skin to work better. We’re not looking to change our features. We want them refreshed. Brighter. Less tired.
That’s where polynucleotides come in.
At my clinic here in Norwich, I’ve seen a big shift. Clients are getting smarter, more informed. They’re no longer asking, “Can you plump this?” They’re asking, “Can you make my skin healthier?” And honestly? Polynucleotides might be the best answer we’ve had in years.
2. What Are Polynucleotides?
Here’s the science bit, but I’ll keep it simple. Polynucleotides are DNA fragments, usually from salmon. Sounds strange, but it’s all about compatibility with our skin. What they do is clever. They act like messengers. Once injected, they tell your skin to regenerate, repair and rehydrate. It’s not about stuffing anything in. It’s about waking up your skin so it does what it used to do on its own.
We call it regenerative aesthetics. I call it a skin reset.
3. How They Work
Instead of filling or freezing, polynucleotides stimulate your skin to:
Produce more collagen and elastin
Retain hydration better
Calm inflammation
Heal itself at a cellular level
They trigger fibroblasts (the builders in your skin) to start fresh work. So, over time, you’ll notice your skin looks smoother, plumper and brighter, without ever looking “done.”
It’s subtle, but powerful.
4. Benefits
Here’s what my clients love most about this treatment:
You get a hydrated, dewy finish, not puffiness
It softens fine lines without freezing expression
It’s ideal for the under-eye area (where fillers can go wrong)
Minimal downtime
It’s gentle, which makes it great for sensitive or mature skin
This is a treatment you can build on. Results get better with time, not worse.
5. Who It’s For
If your skin feels dry, dull or “just not what it used to be,” polynucleotides could be perfect.
You’ll likely love this if:
You’re in your late 20s to 60s
You’ve had sun damage or pigmentation
You’ve lost skin bounce and elasticity
You want to try something natural-looking
You’ve been hesitant about fillers, but still want a change
It’s also brilliant if you’ve had treatments like laser or microneedling and want to speed up healing.
6. What to Expect
Here’s what a typical appointment looks like:
Time: 30 to 45 minutes
Comfort: We apply numbing cream. Most people say it’s a 2/10 on the pain scale.
Recovery: A little redness or swelling is normal. It usually settles within 24 hours.
Results: This is a slow-burn treatment. You’ll start to see changes at 2–3 weeks. Best results after 2 or 3 sessions.
We usually recommend a course of 3, spaced 3–4 weeks apart.
7. Polynucleotides vs Fillers
These aren’t the same as hyaluronic acid fillers. Here’s how they compare:
Feature | Polynucleotides | HA Fillers |
Goal | Skin repair & quality | Add volume / reshape |
Suitable for eyes | Yes | Risky |
Results timeline | Gradual (2–8 weeks) | Immediate |
Look | Subtle, fresh | Full, defined |
Longevity | 6–12 months | 6–18 months |
We sometimes use both — polynucleotides to prep the skin, and filler later for volume. It’s all about what you need.
8. Are They Safe?
Yes. 100%. The polynucleotides we use are CE-approved, medical-grade, and have a strong safety profile. They’re actually used in hospitals to help tissue heal — especially after burns or eye surgery. In our clinic, we’re extra cautious. We use cannulas for sensitive areas, sterile protocols and follow-up checks.
9. Results
What can you expect?
Here’s what clients have told me after their second session:
“My under-eyes look smoother and less hollow.”
“My makeup sits better.”
“I didn’t expect this glow!”
The results sneak up on you in the best way. One day, you’ll just notice your reflection looks a bit… happier.
10. Pricing
We keep our pricing honest. No hidden costs. No upsells.
Under-eye: From £180
Full face: From £220
Course of 3: From £600
We’ll recommend what’s best for you based on your skin and your goals.
11. Why Choose Us
There are lots of places offering injectables. But here’s why clients stick with us:
I don’t oversell. If you don’t need it, I’ll tell you.
We focus on skin health, not just trends.
You’ll get proper medical care, not a sales pitch.
Our aftercare is solid. You won’t leave wondering what to do.
We believe in staying natural. Enhancing, not altering.
If you want to feel like yourself, just fresher, we’re your clinic.
12. FAQs
Q: How long does it last?A: Up to 12 months, depending on lifestyle and skin type.
Q: Is it safe for all skin types?A: Yes. It’s suitable for sensitive, mature, or post-procedure skin.
Q: Can I combine it with other treatments?A: Absolutely. It works well with microneedling, Botox, Profhilo, and gentle filler work.
Q: How soon will I see a difference?A: Most clients notice a difference at 3–4 weeks, especially with a second treatment.
13. Book a Free Consultation
If this sounds like what your skin has been waiting for, let’s chat.
Book a free consultation, no pressure, just clear advice.
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